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Novel method for the treatment of Non-Hodgkin's Lymphomas (NHL)

Country of Origin: Spain
Reference Number: TOES20210422002
Publication Date: 22 April 2021

Summary

A Spanish university has developed a technology that uses the tumor suppressor function of a specific gene to offer new therapeutic and prognostic opportunities for the treatment of DLBCL (diffuse large B-cell lymphoma) based on the genetic variations present in each individual patient. The university is looking for partners from companies related to the molecular diagnosis of diseases, mainly Non-Hodgkin's lymphomas and DLBCL, interested in licensing this technology.

Description

Diffuse large B-cell lymphoma is the most common type of Non-Hodgkin's Lymphomas (NHL). With an annual incidence of more than 100,000 cases worldwide, it is noted for its high aggressiveness and heterogeneity, both clinical and genetic, which limits the existence of effective treatment. Although more than half of these patients can achieve long-term remission, it remains a challenging clinical problem with approximately one-third of patients not being cured by standard immunochemotherapy regimens.

Among its molecular subtypes predominate the germinal center B cells (GCB) and the activated B cell variety (ACB), both characterized by their different gene expression profiles.

A Spanish university has shown for the first time the tumor suppressing role of the BCL7A gene and the functional impact that some of its genetic variations have on the development of DLBCL.

Genetic mutations mapped in exon 1 and intron 1 splicing sites of the BCL7A gene have been identified mostly in DLBCL patients with the GCB subtype. Such mutations cause the loss of the amino-terminal domain of BCL7A, resulting in a truncated protein.

The present technology provides the use of BCL7A and the detection of its expression products to offer a novel tool for the treatment of DLBCL in terms of drug detection, prognosis, diagnosis and treatment.

The university is looking for partners interested in licensing this technology.

Advantages and Innovations

• Diagnosis of the disease based on BCL7A mutations. These mutations are more frequent in diffuse large B-cell lymphomas (DLBCL), and more specifically in the specific germinal center subtype (GCB).

• Mutations are concentrated in a specific region of the BCL7A gene (first exon and splicing donor of intron 1) and occur exclusively somatically in tumors, making the analysis of tumor cells easier.

• In vitro and in vivo evidence. Restoration of BCL7A correlates with a tumor suppressor effect. These mutations abrogate the ability of BCL7A to bind to the SWI / SNF complex to perform its function.

• BCL7A expression levels are used to classify patients according to their prognosis.

• New tool for the development of new epigenetic drugs against cancer that targets histone marks with greater precision than previous generations.

• No specific equipment is necessary. The detection of the expression products of BCL7A can be carried out by a great variety of techniques, generally common and accessible in laboratories of the sector.

• Simple method. The possibility of using a kit or device makes it easier to obtain data to diagnose and predict this type of lymphoma.

Stage Of Development

Under development/lab tested

Requested partner

The university is looking for pharmaceutical or other health/medical companies that are working with the molecular diagnosis of diseases. The university is interested in licensing this technology in order to bring it to the market.

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