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An Italian University offers a license for a simple, practical and inexpensive system for the growth of neuronal cells.

Country of Origin: Italy
Reference Number: TOIT20170731001
Publication Date: 31 July 2017


The technology offered relates to a scaffold for the growth and/or differentiation of neuronal precursors mainly constituted by protein nanotubes as well as to an in vitro method for carrying out either the growth or the differentiation of neuronal precursors. Partners such as producers and developers of biocompatible and/or disposable materials for research and medical field are sought. Partners interested in acquiring know-how or patent licenses are sought through a license agreement.


Tissue engineering is a multidisciplinary science that allows the design and the formation of new tissues in order to create biological substitutes that allow to improve, to repair or treat biological tissues are present within the human body.
Many strategies used in this area depend on the use of a material scaffold. This acts as a synthetic extracellular matrix (ECM), organizes cells into a three-dimensional architecture and releases stimulating substances that direct the growth and formation of the desired tissue. The scaffold in addition to providing a support must be able to increase and diversify the cells that are made to take root, must also respond to the specific mechanical characteristics depending on the tissue that you want to regenerate: suitable mechanical properties, porosity and permeability to allow cell development.
In this context, a team of researchers of an Italian University established in 1952 has developed an invention that relates to the use of a scaffold of recombinant proteins for the preparation of plates for cell cultures to be used for the development of biomaterials for neuro-regenerative medicine. The innovation consists of being able to have a system of growth for neuronal cells that is simple, practical and economical. Nor does it require the use of expensive and delicate growth factors.
In addition, an implant suitable to be implanted into the body of an animal comprising said scaffold is also possible.
The research group is looking for producers and/or developers of biocompatible materials for neuro-regenerative medicine and/or disposable materials in the research and medical fields who are willing to acquire one or more know-how/patent licenses.

Advantages and Innovations

The application fields of this technology are within the production of disposable materials for research laboratories and biocompatible materials for research activities and medical use. In respect of the state of the art, the benefits of patent-pending technology can be multiple. The first advantage is the marketing of an innovative product in the field of "disposable" materials for neuronal cell cultures, with potential in the fields of neurobiology and neurophysiology. Another one is the simplicity and ease of use and from an industrial point of view there is a scalable production with low costs. Moreover, biocompatible scaffolds could enter the market for low-cost "artificial tissues". Moreover, the scaffold protein could be used also for the neural tissue regeneration for medical use.

Stage Of Development

Prototype available for demonstration

Requested partner

Type of partner sought:

Specific area of activity of the partner:
Producers of biocompatible and/or disposable materials for research and medical field. Producers or developers of biomaterials for neuroregenerative medicine.

Task to be performed by the partner sought:
Acquiring one or more know how or patent licences.

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