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Dietary supplement to prevent the formation of advanced glycation end products in diabetic patients

Country of Origin: Spain
Reference Number: TOES20151013003
Publication Date: 11 December 2015

Summary

Researchers from a Spanish university have developed and patented a dietary composition based on phytate to prevent the formation of advanced glycation end products (AGE), toxic substances present in diseases such as diabetes. Companies engaged in diabetic nutrition and supplementations interested in a license agreement are being sought.

Description

Advanced glycation end products (AGEs) are substances resulting from the chemical reaction –an attachment, between a sugar molecule (as glucose) and an amino acid, most of which are harmful to people, especially for diabetics because of their higher glucose levels. These substances can be a factor in the development or worsening of many degenerative diseases, such as diabetes, chronic renal failure or Alzheimer’s disease. In diabetes, AGEs are the responsible for microvascular and macrovascular complications (nephropathy, neuropathy). 



Phytate is a natural product presents in our diet (legumes and cereals) which is demonstrated to have an important inhibitory effect on AGEs formation. Interestingly, diabetic patients follow a diet low in rich-phytate foods and their physiological levels of phytate are extremely low. For these reasons, a supplementation of phytate would be very important in order to avoid or retard future complications in these patients



Spanish researchers specialized in the field of renal lithiasis and nutrition have developed a new composition based on phytate and vitamers to prevent the formation of AGEs, so that they can be used therapeutically in the treatment or prevention of diseases such as neuropathy, nephropathy, atherosclerosis, vascular calcification and neurodegenerative diseases. 



Companies engaged in diabetic nutrition interested in a license agreement for developing a supplement are being sought.

Advantages and Innovations

One of the therapeutic approaches is preventing the formation of AGE through inhibitors. One of these inhibitors is the Metformin. As an alternative, the developed dietary composition is based on natural products –phytate and vitamin B6, avoiding adverse effects to health and having a high inhibitory capacity for the formation of AGE.

Stage Of Development

Available for demonstration

Requested partner

Companies engaged in diabetic nutrition interested in a license agreement for developing a supplement are being sought.